Reply 2:
I have manually created a Macroworks 3 folder in "users etc" then ran the program again, chose a loco in screen that comes up then opened TSW2020, chose a train to drive (This case a class 47) and some of the controls work in a fashion. For example, the throttle moved a bit and in the wrong direction, the horn works ok, the rest move but in the wrong direction or just a little etc, etc. It is almost like they are not calibrated properly even though I have used RD calibration tool on many occasions. (It works fine in TS2020!)
Something is obviously out of sinc!
Hoping this little extra info might be useful.